ÑóẊîöʼn
23rd November 2008, 13:18
"Surgeons in Spain have carried out the world's first tissue-engineered whole organ transplant - using a windpipe made with the patient's own stem cells.
The groundbreaking technology also means for the first time tissue transplants can be carried out without the need for anti-rejection drugs.
Five months on the patient, 30-year-old mother-of-two Claudia Castillo, is in perfect health, The Lancet reports.
She needed the transplant to save a lung after contracting tuberculosis.
The disease had damaged her airways.
Scientists from Bristol helped grow the cells for the transplant and the European team believes such tailor-made organs could become the norm.
To make the new airway, the doctors took a donor windpipe, or trachea, from a patient who had recently died.
Then they used strong chemicals and enzymes to wash away all of the cells from the donor trachea, leaving only a tissue scaffold made of the fibrous protein collagen.
This gave them a structure to repopulate with cells from Ms Castillo herself, which could then be used in an operation to repair her damaged left bronchus - a branch of the windpipe.
By using Ms Castillo's own cells the doctors were able to trick her body into thinking the donated trachea was part of it, thus avoiding rejection."
Read more here (http://news.bbc.co.uk/2/hi/health/7735696.stm)
This is fantastic news. Now that we know how to do such things with relatively simple organs, it won't be too long before we perform this procedure with more complicated organs.
The groundbreaking technology also means for the first time tissue transplants can be carried out without the need for anti-rejection drugs.
Five months on the patient, 30-year-old mother-of-two Claudia Castillo, is in perfect health, The Lancet reports.
She needed the transplant to save a lung after contracting tuberculosis.
The disease had damaged her airways.
Scientists from Bristol helped grow the cells for the transplant and the European team believes such tailor-made organs could become the norm.
To make the new airway, the doctors took a donor windpipe, or trachea, from a patient who had recently died.
Then they used strong chemicals and enzymes to wash away all of the cells from the donor trachea, leaving only a tissue scaffold made of the fibrous protein collagen.
This gave them a structure to repopulate with cells from Ms Castillo herself, which could then be used in an operation to repair her damaged left bronchus - a branch of the windpipe.
By using Ms Castillo's own cells the doctors were able to trick her body into thinking the donated trachea was part of it, thus avoiding rejection."
Read more here (http://news.bbc.co.uk/2/hi/health/7735696.stm)
This is fantastic news. Now that we know how to do such things with relatively simple organs, it won't be too long before we perform this procedure with more complicated organs.